[Evaluation of fetomaternal hemorrhage in postpartum patients with indication for administration of anti-D immunoglobulin]

• Abstract: This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was then measured by the Kleihauer-Betke test (K-B). The rosette test was positive in 22 cases (6.4%). In five of these cases, K-B did not show fetomaternal hemorrhage (a 1.45% false-positive rate for the rosette test), and in one case the test was inconclusive. There were 8 cases with FMH < 10 ml (2.3%), 6 cases with FMH from 10 to 30 ml (1.7%), and two cases with FMH > 30 ml (0.58%), requiring a supplementary dose of anti-D. The study concludes that following the rosette test, additional evaluation of FMH using a quantitative test was unnecessary in 93.6% of the cases.
• Authors: Eduardo Baiochi, Luiz Camano, José Orlando Bordin (Affiliation: Departamento de Obstetrícia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. baiochi.toco at epm.br)
• Journal: Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública (Cad Saude Publica) 2005 Sep-Oct Vol. 21 Issue 5 Pg. 1357-65 ISSN: 0102-311X [Print] Brazil
• Vernacular Title: Avaliação da hemorragia feto-materna em puérperas com indicação para ministração de imunoglobulina anti-D.
• PMID: 16158140 (Publication Type: English Abstract, Journal Article)

Chemical References

• Rho(D) Immune Globulin

Topics

• Adult
• Blood Volume
• Female
• Fetomaternal Transfusion (physiopathology, therapy)
• Humans
• Postpartum Period
• Pregnancy
• Rh Isoimmunization (prevention & control)
• Rho(D) Immune Globulin (administration & dosage, therapeutic use)
• Triage (economics, methods)