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Autonomic function after botulinum toxin type A or B: a double-blind, randomized trial.

Abstract
To compare autonomic effects of botulinum toxin (BTX), we randomized patients with cervical dystonia to receive either BTX-A or BTX-B in a double-blind manner. Efficacy and physiologic questionnaire measures of autonomic function were assessed at baseline and 2 weeks after injection. Patients treated with BTX-B had less saliva production (p < 0.01) and greater severity of constipation (p = 0.037) than those treated with BTX-A, but did not differ in other tests of autonomic functions.
AuthorsR Tintner, R Gross, U F Winzer, K A Smalky, J Jankovic
JournalNeurology (Neurology) Vol. 65 Issue 5 Pg. 765-7 (Sep 13 2005) ISSN: 1526-632X [Electronic] United States
PMID16157918 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Neuromuscular Agents
  • rimabotulinumtoxinB
  • Botulinum Toxins
  • Botulinum Toxins, Type A
Topics
  • Adolescent
  • Adult
  • Aged
  • Autonomic Nervous System (drug effects, physiopathology)
  • Autonomic Nervous System Diseases (chemically induced, physiopathology)
  • Botulinum Toxins (administration & dosage, adverse effects)
  • Botulinum Toxins, Type A (administration & dosage, adverse effects)
  • Cardiovascular Physiological Phenomena (drug effects)
  • Cholinergic Fibers (drug effects, physiology)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Enteric Nervous System (drug effects, physiopathology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuromuscular Agents (administration & dosage, adverse effects)
  • Presynaptic Terminals (drug effects, physiology)
  • Reflex, Pupillary (drug effects, physiology)
  • Respiratory Physiological Phenomena (drug effects)
  • Salivation (drug effects)
  • Torticollis (drug therapy)

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