Abstract |
To compare autonomic effects of botulinum toxin (BTX), we randomized patients with cervical dystonia to receive either BTX-A or BTX-B in a double-blind manner. Efficacy and physiologic questionnaire measures of autonomic function were assessed at baseline and 2 weeks after injection. Patients treated with BTX-B had less saliva production (p < 0.01) and greater severity of constipation (p = 0.037) than those treated with BTX-A, but did not differ in other tests of autonomic functions.
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Authors | R Tintner, R Gross, U F Winzer, K A Smalky, J Jankovic |
Journal | Neurology
(Neurology)
Vol. 65
Issue 5
Pg. 765-7
(Sep 13 2005)
ISSN: 1526-632X [Electronic] United States |
PMID | 16157918
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuromuscular Agents
- rimabotulinumtoxinB
- Botulinum Toxins
- Botulinum Toxins, Type A
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Topics |
- Adolescent
- Adult
- Aged
- Autonomic Nervous System
(drug effects, physiopathology)
- Autonomic Nervous System Diseases
(chemically induced, physiopathology)
- Botulinum Toxins
(administration & dosage, adverse effects)
- Botulinum Toxins, Type A
(administration & dosage, adverse effects)
- Cardiovascular Physiological Phenomena
(drug effects)
- Cholinergic Fibers
(drug effects, physiology)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Enteric Nervous System
(drug effects, physiopathology)
- Female
- Humans
- Male
- Middle Aged
- Neuromuscular Agents
(administration & dosage, adverse effects)
- Presynaptic Terminals
(drug effects, physiology)
- Reflex, Pupillary
(drug effects, physiology)
- Respiratory Physiological Phenomena
(drug effects)
- Salivation
(drug effects)
- Torticollis
(drug therapy)
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