Abstract | OBJECTIVE: METHODS: Male Wistar rats were fed diets containing 5% CBH for various days (1 to 14 d). On the final day of feeding rats were treated with GalN (400 mg/kg), and their plasma transaminase (aspartate and alanine aminotransferases) activity (6 or 24 h later) and liver glutathione concentration (6 h later) were determined. RESULTS: Ingested CBH suppressed the increase in plasma aspartate and alanine aminotransferase activities 24 h after GalN treatment. Such suppressive effect was observed only 7 d after CBH ingestion and not after 1 or 3 d. In the early phase of the liver injury, at 6 h after GalN treatment, the liver glutathione concentration in the CBH group was significantly higher than that in the control group, and the concentration in the CBH group after GalN injection was almost the same as that in the control group without GalN treatment. CONCLUSION: Results suggest that dietary CBH suppresses the development of hepatic injury by GalN in rats and that this phenomenon is partly attributable to the increase in hepatic glutathione concentration by CBH.
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Authors | Ayako Daizo, Yukari Egashira, Hiroo Sanada |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 21
Issue 10
Pg. 1044-51
(Oct 2005)
ISSN: 0899-9007 [Print] United States |
PMID | 16157242
(Publication Type: Journal Article)
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Chemical References |
- Dietary Fiber
- Polysaccharides
- Galactosamine
- hemicellulose
- Aspartate Aminotransferases
- Alanine Transaminase
- Glutathione
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Topics |
- Alanine Transaminase
(blood)
- Analysis of Variance
- Animals
- Aspartate Aminotransferases
(blood)
- Dietary Fiber
(administration & dosage, pharmacology)
- Digestion
- Galactosamine
(toxicity)
- Glutathione
(drug effects, metabolism)
- Liver
(drug effects, enzymology, pathology)
- Male
- Polysaccharides
(administration & dosage, pharmacology)
- Rats
- Rats, Wistar
- Solubility
- Spleen
(metabolism)
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