Analytical determination of the distribution of flumethrin on the body surface of cattle following topical pour-on application.

Abstract

By means of chemical analysis, the distribution behaviour of flumethrin was determined in the hair coat of cattle following topical pour-on application. Flumethrin was applied at 1 mg active ingredient (a.i.) kg-1 body weight along the backline of cattle. It was demonstrated that this compound could be recovered from all hair samples taken on Day 1 following application from dorsal, lateral, ventral and distal body regions in concentrations ranging from 670 to 1 micrograms a.i. g-1 hair, depending on the distance from the site of application. On Days 3, 5 and 10 after treatment, the corresponding concentrations were 125.0-1.5, 23.0-1.0, and 44.0-0.9 micrograms a.i. g-1 hair, respectively. When correlating these values to the body surface of cattle, it is evident that on all sample days and body regions, a concentration of more than 0.01 microgram a.i. cm-2 body surface was present. This amount of active substance is sufficient for effective acaricidal action, as shown by laboratory and field data.

• Authors: W Stendel, H D Hamel, H U Sieveking, D Brühne
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 42 Issue 1-2 Pg. 137-43 (Apr 1992) ISSN: 0304-4017 [Print] Netherlands
• PMID: 1615624 (Publication Type: Journal Article)

Chemical References

• Pyrethrins
• flumethrin

Topics

• Administration, Topical
• Animals
• Cattle (metabolism)
• Hair (chemistry, metabolism)
• Pyrethrins (administration & dosage, pharmacokinetics)