HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Variations in plasma apolipoprotein C-III levels are strong correlates of the triglyceride response to a high-monounsaturated fatty acid diet and a high-carbohydrate diet.

Abstract
The objective of this study was to examine how a diet rich in carbohydrates (high-CHO) vs a diet rich in monounsaturated fatty acids (high MUFA) consumed ad libitum modulated plasma apolipoprotein C-III (apo C-III) levels and to examine the extent to which diet-induced changes in plasma apo C-III were associated with concurrent variations in plasma triglyceride (TG) levels. Forty-seven men (mean age, 35.7 +/- 11.4 years; body mass index, 29.0 +/- 5.1 kg/m2) were randomly assigned to either a high-CHO diet (CHO, 58%; fat, 26%; n = 23) or a high-MUFA diet (CHO, 45%; fat, 40%; MUFA, 22.5%; n = 24), which they consumed for 6 to 7 weeks. Fasting and postprandial lipemia after an oral fat load and fasting plasma apo C-III were measured at the beginning and at the end of the dietary intervention. Ad libitum consumption of the high-CHO diet induced a significant reduction in body weight (-2.6%, P < .0001), but had no impact on plasma apo C-III concentrations and on fasting and postprandial plasma TG levels. In contrast, ad libitum consumption of the high-MUFA diet also resulted in a significant reduction in body weight (-2.3%, P < .01) as well as in significant reductions in plasma apo C-III (-11%, P = .05) and fasting plasma TG (-17%, P < .01). Diet-induced variations in plasma apo C-III concentrations were correlated with changes in fasting and postprandial TG levels both in the high-CHO (r > 0.70, P < .001) and the high-MUFA groups (r > 0.42, P < .05). These results indicate that variations in plasma apo C-III levels are strong correlates of the fasting and postprandial plasma TG responses to high-MUFA and high-CHO diets.
AuthorsW Roodly Archer, Sophie Desroches, Benoît Lamarche, Olivier Dériaz, Nancy Landry, Bénédicte Fontaine-Bisson, Jean Bergeron, Patrick Couture, Nathalie Bergeron
JournalMetabolism: clinical and experimental (Metabolism) Vol. 54 Issue 10 Pg. 1390-7 (Oct 2005) ISSN: 0026-0495 [Print] United States
PMID16154441 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoprotein C-III
  • Apolipoproteins C
  • Cholesterol, HDL
  • Dietary Carbohydrates
  • Dietary Fats, Unsaturated
  • Lipoproteins, VLDL
  • Triglycerides
  • very low density lipoprotein triglyceride
Topics
  • Adult
  • Apolipoprotein C-III
  • Apolipoproteins C (blood)
  • Cholesterol, HDL (blood)
  • Dietary Carbohydrates (administration & dosage)
  • Dietary Fats, Unsaturated (administration & dosage)
  • Humans
  • Lipoproteins, VLDL (blood)
  • Male
  • Middle Aged
  • Regression Analysis
  • Triglycerides (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: