Abstract | BACKGROUND: A recent study suggested that administration of androstenediol (Adiol) after trauma- hemorrhage (T-H) improves hepatic functions; however, the mechanism responsible for the salutary effect of Adiol remains unknown. Although studies indicate similarities and association between the anti-inflammatory properties of Adiol and peroxisome proliferator-activated receptor gamma ( PPARgamma), whether the salutary effects of Adiol are mediated via upregulation of PPARgamma remains unclear. METHODS: RESULTS: CONCLUSIONS: Since blockade of PPARgamma prevented the salutary effects of Adiol on hepatic functions and proinflammatory factors, this finding suggests that Adiol mediated its salutary effects after T-H via the PPARgamma-related pathways.
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Authors | Tomoharu Shimizu, Laszlo Szalay, Ya-Ching Hsieh, Mashkoor A Choudhry, Kirby I Bland, Irshad H Chaudry |
Journal | Surgery
(Surgery)
Vol. 138
Issue 2
Pg. 204-11
(Aug 2005)
ISSN: 0039-6060 [Print] United States |
PMID | 16153428
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- 2-chloro-5-nitrobenzanilide
- Anabolic Agents
- Anilides
- Endothelin-1
- NF-kappa B
- PPAR gamma
- Transcription Factor AP-1
- Tumor Necrosis Factor-alpha
- C-Reactive Protein
- Androstenediol
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
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Topics |
- Anabolic Agents
(pharmacology)
- Androstenediol
(pharmacology)
- Anilides
(pharmacology)
- Animals
- C-Reactive Protein
(metabolism)
- Endothelin-1
(blood, genetics)
- Gene Expression
(drug effects)
- Hemorrhage
(drug therapy)
- Liver
(drug effects, physiology)
- Male
- NF-kappa B
(metabolism)
- Nitric Oxide Synthase
(genetics)
- Nitric Oxide Synthase Type II
- PPAR gamma
(antagonists & inhibitors, genetics, metabolism)
- Rats
- Rats, Sprague-Dawley
- Transcription Factor AP-1
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
- Wounds and Injuries
(drug therapy)
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