[Progress of cardiovascular pharmacologic study on berbamine].

Abstract

Berbamine (molecular formular C37H40N2O6) is a bi-benzle-isoquinolyl alkaloid extracted from Berberis poiretil Schneid (genus of Berberis, family of Beridaceae), a kind of Chinese plants. In aspect of cardiovascular pharmacology, berbamine shows actions of anti-arrhythmia, anti-myocardial ischemia, vasodilatating to lower blood pressure, and antithrombosis, it could lower heart function and heart rate. Study on its anti-arrhythmia was the deepest one. The significant anti-arrhythmia action can be achieved by inhibiting ionic channels of sodium, potassium, calcium, etc., negative frequency and negative transduction, improving the diastolic excitation threshold of myocardium, prolonging effective refractory period of myocardium. As a direction of researches on new type of antiarrhythmic herbs and herbal drugs, the study on berbamine is worthy of further research and development.

• Authors: Zhi-Bin Guo, Jin-Guo Fu
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 25 Issue 8 Pg. 765-8 (Aug 2005) ISSN: 1003-5370 [Print] China
• PMID: 16152843 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Alkaloids
• Anti-Arrhythmia Agents
• Antihypertensive Agents
• Benzylisoquinolines
• Platelet Aggregation Inhibitors
• berbamine

Topics

• Alkaloids (pharmacology)
• Anti-Arrhythmia Agents (pharmacology)
• Antihypertensive Agents (pharmacology)
• Benzylisoquinolines (pharmacology)
• Heart Rate (drug effects)
• Ion Channel Gating (drug effects)
• Platelet Aggregation
• Platelet Aggregation Inhibitors (pharmacology)