Effect of triacontanol on numbers and functions of cells involved in inflammatory responses.

Abstract

A preparation of a triacontanol-containing compound was studied for its effect on cells involved in the inflammatory response. C57BL/6 mice were injected intraperitoneally with various concentrations of this compound and investigated for total body weight, wet weight of thymus tissue, number of thymus cells and splenocytes, interleukin 1 production of spleen monocytes, and response of splenocytes to the T cell mitogen, phytohemagglutinin. Mice treated with the triacontanol preparation exhibited decreased total body weight, 24% reduction in thymus weights, 39% decrease in the number of thymus cells, and 21% depression in total splenocytes. Splenic monocytes of these animals produced a significantly reduced amount of interleukin 1 and splenocytes had a significantly depressed response to phytohemagglutinin. It is concluded that triacontanol has an inhibitory effect on at least some of the cells responsible for inflammation.

• Authors: R P Warren, R A Burger, R W Sidwell, L L Clark
• Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (Proc Soc Exp Biol Med) Vol. 200 Issue 3 Pg. 349-52 (Jul 1992) ISSN: 0037-9727 [Print] United States
• PMID: 1615010 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Fatty Alcohols
• 1-triacontanol

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Cell Count
• Fatty Alcohols (pharmacology)
• Female
• Inflammation (pathology)
• Lymphocytes (drug effects, physiology)
• Mice
• Mice, Inbred C57BL
• Monocytes (drug effects, physiology)
• Organ Size (drug effects)
• Spleen (drug effects, metabolism, pathology)
• Thymus Gland (drug effects, metabolism, pathology)