D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats.

Abstract

OBJECTIVE:

D-allose, an all-cis aldo-hexose, is non-caloric and possesses antioxidant properties. We investigated the effects of oral D-allose supplementation on the development of high blood pressure and the oxidative status in two genetically hypertensive animal models: Dahl salt-sensitive hypertensive (DS) rats and spontaneously hypertensive rats.

METHODS AND RESULTS:

The systolic blood pressure of DS rats fed a 4% salt diet for 4 weeks significantly increased from 122+/-8 to 161+/-5 mmHg as compared with DS rats fed a normal salt diet (138+/-5 mmHg at 4 weeks), whereas concordant supplementation of D-allose, but not D-glucose, with a dose of 2 g/kg daily to salt-loaded DS rats suppressed the development of high blood pressure (135+/-7 mmHg at 4 weeks), accompanied with decreases in superoxide production in the aorta that was determined by the lucigenin chemiluminescence and dihydroethidium staining. The increases of urinary protein secretion of salt-loaded DS rats were prevented by D-allose supplementation (DS rats fed 0.5% salt, 18.2+/-6.3 mg/day; DS rats fed 4% salt alone, 81.8+/-16.5 mg/day; DS rats fed 4% salt+D-allose, 31.3+/-11.8 mg/day; DS rats fed 4% salt+D-glucose, 85.3+/-20.5 mg/day). On the other hand, D-allose supplementation in spontaneously hypertensive rats had no significant effect on the blood pressure or the aortic superoxide production during the early developing stage of hypertension.

CONCLUSIONS:

These results underscore the role of enhanced oxidative stress in the pathogenesis of high blood pressure development in DS rats, and suggest the possibility of D-allose supplementation for prevention of salt-sensitive hypertension.

• Authors: Shoji Kimura, Guo-Xing Zhang, Akira Nishiyama, Yukiko Nagai, Toshitaka Nakagawa, Hiroshi Miyanaka, Yoshihide Fujisawa, Akira Miyatake, Tsubasa Nagai, Masaaki Tokuda, Youichi Abe
• Journal: Journal of hypertension (J Hypertens) Vol. 23 Issue 10 Pg. 1887-94 (Oct 2005) ISSN: 0263-6352 [Print] England
• PMID: 16148613 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Sodium Chloride, Dietary
• Superoxides
• allose
• NADPH Oxidases
• Mitogen-Activated Protein Kinase 1
• Mitogen-Activated Protein Kinase 3
• Glucose

Topics

• Animals
• Aorta (drug effects, metabolism)
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Dietary Supplements
• Gene Expression Regulation, Enzymologic (drug effects)
• Glucose (administration & dosage, therapeutic use)
• Hypertension (etiology, physiopathology, prevention & control)
• Kidney (pathology)
• Kidney Cortex (metabolism)
• Male
• Mitogen-Activated Protein Kinase 1 (metabolism)
• Mitogen-Activated Protein Kinase 3 (metabolism)
• Myocardium (pathology)
• NADPH Oxidases (genetics)
• Organ Size (drug effects)
• Phosphorylation (drug effects)
• Proteinuria (prevention & control, urine)
• RNA, Messenger (genetics, metabolism)
• Rats
• Rats, Inbred Dahl
• Rats, Inbred SHR
• Sodium Chloride, Dietary (administration & dosage)
• Superoxides (metabolism)