Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome.

Abstract

The objective of this study was to evaluate the clinical and reproductive outcome in clomiphene-citrate (CC)-resistant women with high body mass index (BMI) and primary infertility. This was a case series based at the King Hussein Medical center, Amman, Jordan. Nineteen CC-resistant women with polycystic ovary syndrome (PCOS) who had high BMI and primary infertility were studied. All women received metformin monotherapy; 850 mg twice daily for a period of 6 months. If pregnancy occurred, metformin was continued for the first 12 weeks of pregnancy. The main outcome measures were a reduction in the BMI, resumption of regular menses, ovulation and pregnancy rates. Resumption of regular cycles was observed in 13 of 19 (68.4%) women. Ovulation and pregnancy were achieved in 9 (47.4%) and 6 (31.6%) of the 19 women, respectively. A significant reduction in the body weight after treatment reflected by a significant reduction in the BMI was noted. Metformin monotherapy is effective in CC-resistant women with morbid obesity and primary infertility and should be considered as first-line treatment in these patients.

• Authors: H S Qublan, H Y Malkawi
• Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (J Obstet Gynaecol) Vol. 25 Issue 1 Pg. 55-9 (Jan 2005) ISSN: 0144-3615 [Print] England
• PMID: 16147697 (Publication Type: Journal Article)

Chemical References

• Hypoglycemic Agents
• Clomiphene
• Metformin

Topics

• Adult
• Body Mass Index
• Clomiphene
• Drug Resistance
• Female
• Humans
• Hypoglycemic Agents (administration & dosage)
• Infertility, Female (therapy)
• Metformin (administration & dosage)
• Obesity (complications, drug therapy)
• Ovulation Induction
• Polycystic Ovary Syndrome (complications, drug therapy)
• Pregnancy
• Pregnancy Outcome
• Treatment Outcome
• Weight Loss