Abstract | OBJECTIVE: DESIGN: : This prospective, open, randomized, clinical trial included 100 healthy postmenopausal women. Patients were randomized into four treatment groups, each consisting of 25 women. Treatment consisted of 50 mug/day transdermal 17beta-estradiol for all women combined to receive four different progestogens (group A: medroxyprogesterone acetate, 10 mg/day; group B: nomegestrol acetate, 5 mg/day; group C: dydrogesterone, 10 mg/day; group D: micronized progesterone, 200 mg/day) per os from the 14th to 25th day of each 28-day cycle. The duration of treatment was 12 cycles. Patients were asked to record in a daily diary the occurrence of any vaginal bleeding, the days of application of each patch, the days of assumption of the different progestogens, and the exact moment of bleeding onset. RESULTS: CONCLUSION: : Our data suggest that CS-EPT generally leads to regular withdrawal bleeding in women without uterine pathology. Micronized progesterone seems to induce more irregular bleeding episodes.
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Authors | Costantino Di Carlo, Annalidia Sammartino, Attilio Di Spiezio Sardo, Giovanni A Tommaselli, Maurizio Guida, Vincenzo D Mandato, Antonio D'Elia, Carmine Nappi |
Journal | Menopause (New York, N.Y.)
(Menopause)
2005 Sep-Oct
Vol. 12
Issue 5
Pg. 520-5
ISSN: 1072-3714 [Print] United States |
PMID | 16145305
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Contraceptive Agents, Female
- Norpregnadienes
- Progesterone
- Estradiol
- nomegestrol acetate
- Dydrogesterone
- Medroxyprogesterone Acetate
- Megestrol
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Topics |
- Administration, Cutaneous
- Amenorrhea
(epidemiology)
- Contraceptive Agents, Female
(therapeutic use)
- Dydrogesterone
(therapeutic use)
- Endometrium
(diagnostic imaging)
- Estradiol
(therapeutic use)
- Estrogen Replacement Therapy
(methods)
- Female
- Humans
- Medroxyprogesterone Acetate
(therapeutic use)
- Megestrol
(therapeutic use)
- Middle Aged
- Norpregnadienes
(therapeutic use)
- Postmenopause
- Progesterone
(therapeutic use)
- Prospective Studies
- Ultrasonography
- Uterine Hemorrhage
(chemically induced)
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