Abstract | AIM: METHODS: RESULTS: In preparations of rat Langendorff hearts, infusion of oxyphenamone (1-10 micromol.L(-1)) diminished the incidence of ventricular fibrillation, decreased the activities of CPK and LDH in coronary efflux, and antagonized the increase of MDA content in ischemic myocardium significantly. The ischemia-reperfusion injury in anesthetized rats produced severe ventricular arrhythmia, decrease of CPK in myocardium, increase of CPK in serum, increase both of LDH and MDA both in myocardium and in serum, and severe damage of myocardial ultrastructure. Intravenous injection of oxyphenamone 0.1-1.0 mg.kg(-1) 5 min before ischemia ameliorated dose-dependently ventricular arrhythmia, antagonized the changes of CPK, LDH and MDA in both myocardium and serum induced by ischemia-reperfusion. It even maintained these parameters at normal level. The effects were somewhat similar to that of verapamil 1.0 mg.kg(-1) Intravenous injection of oxyphenamone 0.5 or 1.0 mg.kg(-1) 5 min after ligation of LAD also antagonized the ischemia-reperfusion induced changes in CPK, LDH and MDA in myocardium and serum significantly, and ameliorated the damage of myocardial ultrastructure markedly. The therapeutic effects of oxyphenamone were similar to that of propranolol 2. 0 mg.kg(-1). CONCLUSION:
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Authors | Li-Li Fan, Jian Teng, Run-Dong Zhang, De-Yu Zhao |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 40
Issue 6
Pg. 507-12
(Jun 2005)
ISSN: 0513-4870 [Print] China |
PMID | 16144314
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organic Chemicals
- Protective Agents
- oxyphenamone
- Malondialdehyde
- L-Lactate Dehydrogenase
- Creatine Kinase
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Topics |
- Animals
- Creatine Kinase
(blood, metabolism)
- Female
- In Vitro Techniques
- L-Lactate Dehydrogenase
(blood, metabolism)
- Male
- Malondialdehyde
(blood, metabolism)
- Myocardial Ischemia
(complications)
- Myocardial Reperfusion Injury
(etiology, metabolism, pathology)
- Myocardium
(metabolism, pathology, ultrastructure)
- Organic Chemicals
(pharmacology)
- Protective Agents
(pharmacology)
- Random Allocation
- Rats
- Rats, Wistar
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