Abstract | OBJECTIVE: METHODS: Sera from 10 Japanese and 22 North American PM/DM patients with anti-SRP antibodies were tested for the presence of anti-7SL RNA antibodies, using the sera to immunoprecipitate deproteinized RNA extracts derived from HeLa cells. RESULTS: The immunoprecipitation analysis indicated that 5 Japanese (50%) and one North American (5%) patient with anti-SRP antibodies had novel autoantibodies against deproteinized 7SL RNA. The frequency of anti-7SL RNA antibodies was significantly higher in Japanese than North American patients (p = 0.006). The presence of anti-7SL RNA antibodies appeared to be associated with DM (2 patients) and finger swelling (2 PM patients). The seasonal onset of the disease was different (p = 0.008) for Japanese PM/DM patients with anti-7SL RNA antibodies, who developed the disease between October and January (mean month November; p = 0.01) from that of patients without these antibodies, who developed it between June and August (mean month July; p = 0.01). CONCLUSION: Novel autoantibodies against 7SL RNA were identified in patients with PM/DM, and the presence of these antibodies was correlated to ethnic background, clinical features, and season of disease onset. These findings indicated that autoantibodies against 7SL RNA are a novel serological marker for a subset of PM/DM cases.
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Authors | Takashi Satoh, Tetsuroh Okano, Toshimichi Matsui, Hiroyuki Watabe, Takashi Ogasawara, Kouya Kubo, Masataka Kuwana, Noreen Fertig, Chester V Oddis, Hirobumi Kondo, Tohru Akahoshi |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 32
Issue 9
Pg. 1727-33
(Sep 2005)
ISSN: 0315-162X [Print] Canada |
PMID | 16142868
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 7SL RNA
- Autoantibodies
- Biomarkers
- RNA, Small Cytoplasmic
- Signal Recognition Particle
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Topics |
- Adult
- Asian People
- Autoantibodies
(analysis, immunology)
- Biomarkers
- Cohort Studies
- Dermatomyositis
(blood, ethnology, immunology)
- Female
- Follow-Up Studies
- Humans
- Immunoprecipitation
- Male
- Middle Aged
- Polymyositis
(blood, ethnology, immunology)
- Probability
- RNA, Small Cytoplasmic
(analysis, immunology)
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
- Signal Recognition Particle
(analysis, immunology)
- White People
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