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The effect of non-steroidal anti-inflammatory drugs on inflammatory cystoid macular edema.

AbstractPURPOSE: To assess the role of systemic non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of inflammatory cystoid macular edema (iCME). DESIGN: Pilot study. METHODS: We included 66 patients with iCME and treated them with naproxen (2 x 250 mg daily; n = 28) or rofecoxib (1 x 25 mg daily; n = 38). After 4 months of therapy, visual acuity and inflammation activity were measured. We evaluated the grade of CME, retinal vasculitis, and papillary leakage with fluorescein angiography. RESULTS: No clear effect of NSAIDs on iCME, visual acuity, and intraocular inflammation was observed. A beneficial effect was noted in less than 8% of the affected eyes. The drop-out rate after 4 months of treatment was 52%, because of adverse effects or inefficacy of the treatment. Improvement of visual acuity was slightly better in patients who were treated with naproxen compared with rofecoxib (P < or = .05). CONCLUSION: Systemic NSAIDs have a limited role (if any) in the treatment of iCME.
AuthorsBram van Kooij, Joke De Boer, Ninette Ten Dam, Rob Fijnheer, Aniki Rothova (Affiliation: Department of Ophthalmology, F.C. Donders Institute of Ophthalmology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. h.vankooij at oogh.azu.nl)
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 140 Issue 3 Pg. 563-4 (Sep 2005) ISSN: 0002-9394 [Print] United States
PMID16139022 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Lactones
  • Sulfones
  • rofecoxib
  • Naproxen
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Child
  • Female
  • Fluorescein Angiography
  • Humans
  • Lactones (therapeutic use)
  • Macular Edema (drug therapy)
  • Male
  • Middle Aged
  • Naproxen (therapeutic use)
  • Pilot Projects
  • Retinal Vasculitis (drug therapy)
  • Sulfones (therapeutic use)
  • Treatment Outcome
  • Visual Acuity

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