Abstract |
The Tibetan herbal remedy PADMA 28 revealed promising results to support treatment of atherosclerosis, Charot syndrome ( intermittent claudication), chronic active hepatitis and infection of the respiratory tract. The remedy was confirmed to be closely linked with anti- and pro-oxidative properties in vitro. In this study, apoptogenic and survival effects of PADMA 28 were investigated in the T cell-derived lymphocytic leukaemia cell line CEM-C7H2. PADMA 28 led to a concentration-dependent inhibition of cell proliferation accompanied by the accumulation of CEM-C7H2 cells in subG1 phase, fragmentation of poly (ADP-ribose) polymerase (PARP) and nuclear body formation. Treatment with PADMA 28 rescued to some extent cells over-expressing Bcl-2 from apoptosis. This finding suggests that the mechanism of action of PADMA 28 may be via interference with Bcl-2 triggered survival pathways.
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Authors | Marcel Jenny, Wolfgang Schwaiger, David Bernhard, Oliver A Wrulich, Daria Cosaceanu, Dietmar Fuchs, Florian Ueberall |
Journal | Journal of carcinogenesis
(J Carcinog)
Vol. 4
Pg. 15
(Sep 02 2005)
ISSN: 1477-3163 [Electronic] India |
PMID | 16138918
(Publication Type: Journal Article)
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