Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts.

Abstract

BACKGROUND:

The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive.

METHODS:

Thirty cases of dentigerous and radicular cysts respectively as well as 15 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki-67 immunohistochemically.

RESULTS:

Expression of CK 17 was discernible in 93.3% of the odontogenic keratocysts, but only in 35.0% of dentigerous and radicular cysts under study (P < 0.001). CK 19 could be detected in 48.3% of dentigerous and radicular cysts, whereas odontogenic keratocysts were completely negative (P < 0.002).

CONCLUSION:

Immunohistochemical detection of CK 17 and 19 seems to be a valuable additional parameter distinguishing between odontogenic keratocysts and other odontogenic--especially dentigerous--cysts which clinically are likely the most significant differential diagnoses in this context. J Oral Pathol Med (2005) 34: 558-64.

• Authors: Christian Stoll, Carolin Stollenwerk, Dieter Riediger, Christian Mittermayer, Joachim Alfer
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 34 Issue 9 Pg. 558-64 (Oct 2005) ISSN: 0904-2512 [Print] Denmark
• PMID: 16138895 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Intermediate Filament Proteins
• KRT20 protein, human
• KRT7 protein, human
• Keratin-20
• Keratin-7
• Keratins

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (analysis)
• Child
• Dentigerous Cyst (classification, pathology)
• Diagnosis, Differential
• Female
• Humans
• Immunohistochemistry
• Intermediate Filament Proteins (analysis)
• Keratin-20
• Keratin-7
• Keratins (analysis)
• Male
• Middle Aged
• Odontogenic Cysts (classification, pathology)
• Radicular Cyst (classification, pathology)