Abstract | BACKGROUND: METHOD: Thirty-six bronchiolitis patients, whose lung lesion had been diagnosed through High Resolution Computerized Tomography (HRCT) of the chest and also pathological study, were divided into two 18-member case and control groups. Both groups were receiving their conventional treatment (inhaled Felixotide and Servent). The case group were treated for 6 months with a combination of 200 microg of interferon gamma-1b (given three times per week subcutaneously) plus 7.5 mg of prednisolone (given once a day), while the control group received their previous conventional medications. Lung function was measured at base line and after 1, 3 and 6 months of treatment. RESULTS: In case and control groups, Forced Expiratory Volume in first second (FEV1) did not have statistical differences at the base line (49.3 +/- 2.9 and 48.7 +/- 4.1, respectively = 0.6), whereas a significant increase was seen in the case group (66.3 +/- 5.4) compared control group (57.3 +/- 8.6) at the subsequent months (P = 0.001 for the difference between the groups). Similar pattern of increase was observed in Forced Vital Capacity (FVC). CONCLUSION:
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Authors | Mostafa Ghanei, Yoones Panahi, Mojtaba Mojtahedzadeh, Ali Reza Hosseini Khalili, Jafar Aslani |
Journal | Pulmonary pharmacology & therapeutics
(Pulm Pharmacol Ther)
Vol. 19
Issue 2
Pg. 148-53
( 2006)
ISSN: 1094-5539 [Print] England |
PMID | 16137903
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Chemical Warfare Agents
- Glucocorticoids
- Interferon-gamma
- Prednisolone
- Mustard Gas
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Topics |
- Adult
- Bronchiolitis Obliterans
(chemically induced, drug therapy, physiopathology)
- Chemical Warfare Agents
(poisoning)
- Drug Therapy, Combination
- Glucocorticoids
(administration & dosage)
- Humans
- Interferon-gamma
(administration & dosage, therapeutic use)
- Iran
- Male
- Mustard Gas
(poisoning)
- Prednisolone
(administration & dosage)
- Randomized Controlled Trials as Topic
- Respiratory Function Tests
- Time Factors
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