Abstract | BACKGROUND: METHODS: RESULTS:
Tumor necrosis at 1 month after PDT was achieved in all treated lesions. Laser treatment was associated with mild pain (n = 8) and transient subclinical hepatotoxicity (n = 21). In one patient, PDT damage to the pancreas was inflicted, and in another patient, PDT damage of the skin occurred, but no serious clinical complications from PDT were reported. Administration of .6 mg/kg of mTHPBC led to transient phlebitis in 10 patients, and 3 patients experienced mild skin phototoxicity after excess light exposure. CONCLUSIONS: Colorectal liver metastases that are ineligible for resection can be safely and effectively treated with interstitial mTHPBC-based PDT.
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Authors | Frederieke H van Duijnhoven, Jeroen P Rovers, Kerstin Engelmann, Zdenko Krajina, Shaun F Purkiss, Frans A N Zoetmulder, Thomas J Vogl, Onno T Terpstra |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 12
Issue 10
Pg. 808-16
(Oct 2005)
ISSN: 1068-9265 [Print] United States |
PMID | 16132377
(Publication Type: Clinical Trial, Phase I, Journal Article)
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Chemical References |
- 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin
- Porphyrins
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Topics |
- Adult
- Aged
- Colorectal Neoplasms
(secondary)
- Female
- Humans
- Infusions, Intravenous
- Laser Therapy
- Liver Neoplasms
(drug therapy, secondary)
- Male
- Middle Aged
- Photochemotherapy
(adverse effects, methods)
- Porphyrins
(therapeutic use)
- Skin
(pathology)
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