The effect of Chinese herbs on the cytokines of rats with endometriosis.

Abstract

OBJECTIVE:

The aim of this study was to study the regulatory function of Chinese medicine-YiWeiNing (YWN) on the cytokines of endometriosis (EM) model rats.

MATERIALS AND METHODS:

After successfully creating EM models of rats, all were separated randomly into five groups: high dose of YWN (5.4 g/100 g), low dose of YWN (1.8 g/100 g), Danazol group (3.6 mg/100 g), a model group, and a false-operation group. They were then reviewed for the variation of the amount of TNF-alpha (tumor necrosis factor-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8).

RESULTS:

The content of TNF-alpha, IL-6, and IL-8 in the peripheral blood of the model group was apparently higher than the false-operation group (p < 0.01), and YWN reduced the amount of TNF-alpha, IL-6, and IL-8 in the serums of the model group's rats. This made these cytokines tend toward normal levels without an apparent variation, when compared with the false-operation group (p > 0.05).

CONCLUSIONS:

YWN can prevent the growth of ectopic endometrium by inhibiting the synthesis and secretion of TNF-alpha, IL-6, and IL-8.

• Authors: Fan Qu, Jue Zhou, Baozhang Ma
• Journal: Journal of alternative and complementary medicine (New York, N.Y.) (J Altern Complement Med) Vol. 11 Issue 4 Pg. 627-30 (Aug 2005) ISSN: 1075-5535 [Print] United States
• PMID: 16131286 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Drugs, Chinese Herbal
• Interleukin-6
• Interleukin-8
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Cytokines (drug effects, metabolism)
• Drugs, Chinese Herbal (administration & dosage, pharmacology)
• Endometriosis (drug therapy, immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Interleukin-6 (metabolism)
• Interleukin-8 (metabolism)
• Models, Animal
• Phytotherapy
• Random Allocation
• Rats
• Time Factors
• Tumor Necrosis Factor-alpha (metabolism)