Modulation of cutaneous wound healing by ozone: differences between young and aged mice.

Abstract

Cutaneous tissues are frequently exposed to prooxidative environments, including UV radiation and air pollutants. Among the latter, ozone (O(3)) is of particular concern because of its high and dominating presence in photochemical smog. It is well known that O(3) depletes small molecular weight antioxidants, oxidizes proteins, induces lipid peroxidation and activates cellular responses in various tissues. Using an in vivo model (SKH-1 hairless mice), the interaction between O(3) exposure (0.5ppmx6h/day) and age was examined in relation to cutaneous wound healing. Compared to younger (8 weeks) mice, older (18 months) mice exposed to O(3) (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IkappaBalpha and TGFbeta protein. These findings support the hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes.

• Authors: Yunsook Lim, Anh D Phung, Ana M Corbacho, Hnin Hnin Aung, Emanuela Maioli, Abraham Z Reznick, Carroll E Cross, Paul A Davis, Giuseppe Valacchi
• Journal: Toxicology letters (Toxicol Lett) Vol. 160 Issue 2 Pg. 127-34 (Jan 05 2006) ISSN: 0378-4274 [Print] Netherlands
• PMID: 16129572 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aldehydes
• Cross-Linking Reagents
• I-kappa B Proteins
• Nfkbia protein, mouse
• Proteins
• Transforming Growth Factor beta
• NF-KappaB Inhibitor alpha
• Ozone
• 4-hydroxy-2-nonenal

Topics

• Aging (physiology)
• Aldehydes (analysis, chemistry)
• Animals
• Cross-Linking Reagents (analysis, chemistry)
• Female
• I-kappa B Proteins (biosynthesis)
• Lipid Peroxidation (drug effects)
• Mice
• Mice, Hairless
• Models, Animal
• NF-KappaB Inhibitor alpha
• Ozone (toxicity)
• Protein Binding
• Proteins (analysis, chemistry)
• Skin (drug effects, injuries, metabolism)
• Transforming Growth Factor beta (biosynthesis)
• Wound Healing (drug effects)