Effects of an aqueous extract of Puerariae flos (Thomsonide) on impairment of passive avoidance behavior in mice.

Abstract

The effects of an aqueous extract of Puerariae flos (Thomsonide) on ethanol-induced learning and memory impairment and scopolamine-induced amnesia were investigated. Thomsonide exerted an ameliorating effect on the impairment of both memory registration and memory retrieval induced by ethanol. These results indicate that Thomsonide has an antiamnesic effect on the central nervous system in alcoholic intoxication and support the traditional use of Puerariae flos for the treatment of alcoholic intoxication. Thomsonide also improved the scopolamine-induced impairment of memory registration in passive avoidance behavior in mice. The results of this study suggest that it may be possible to use Thomsonide for the treatment of age-related memory impairment and dementia.

• Authors: Takashi Yamazaki, Masako Yaguchi, Yoshijiro Nakajima, Tsuyoshi Hosono, Yujiro Niiho, Yoshiro Hibi, Junei Kinjo, Toshihiro Nohara
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 100 Issue 3 Pg. 244-8 (Sep 14 2005) ISSN: 0378-8741 [Print] Ireland
• PMID: 16125021 (Publication Type: Journal Article)

Chemical References

• Central Nervous System Depressants
• Muscarinic Antagonists
• Plant Extracts
• Thomsonide
• Ethanol
• Scopolamine

Topics

• Alzheimer Disease (drug therapy, psychology)
• Animals
• Avoidance Learning (drug effects)
• Central Nervous System Depressants (antagonists & inhibitors, toxicity)
• Ethanol (antagonists & inhibitors, toxicity)
• Male
• Memory (drug effects)
• Memory Disorders (chemically induced, prevention & control)
• Mice
• Muscarinic Antagonists (toxicity)
• Plant Extracts (pharmacology, toxicity)
• Pueraria (chemistry)
• Scopolamine (antagonists & inhibitors, toxicity)