Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series.

• Authors: George R Pettit, Rui Tan, Zbigniew A Cichacz
• Journal: Journal of natural products (J Nat Prod) Vol. 68 Issue 8 Pg. 1253-5 (Aug 2005) ISSN: 0163-3864 [Print] United States
• PMID: 16124771 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Terpenes
• sesterstatin 6

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Indian Ocean
• Leukemia P388
• Mice
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Porifera (chemistry)
• Terpenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured