Abstract | PURPOSE: METHODS: Mice with laser-induced rupture of Bruch's membrane were given intraperitoneal, intravitreous, or periocular injection of CGC-11144, CGC-11150, or vehicle, and after 14 days, they were perfused with fluorescein-labeled dextran, and the area of CNV was measured on choroidal flatmounts by image analysis. In some groups of mice, treatments were started 7 days after rupture of Bruch's membrane to determine the effect of the agent on established CNV. Electroretinograms (ERGs) were performed to assess the effects on retinal function, and histopathology was used to evaluate retinal structure. RESULTS: CONCLUSIONS: Periocular delivery of the polyamine analogues may be a useful approach for the treatment of CNV.
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Authors | Raquel Lima e Silva, Yoshitsugu Saishin, Yumiko Saishin, Hideo Akiyama, Shu Kachi, Sadia Aslam, Brian Rogers, Tye Deering, Yuan Yuan Gong, Sean F Hackett, Hong Lai, Benjamin J Frydman, Aldonia Valasinas, Laurence J Marton, Peter A Campochiaro |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 46
Issue 9
Pg. 3323-30
(Sep 2005)
ISSN: 0146-0404 [Print] United States |
PMID | 16123436
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biogenic Polyamines
- CGC-11144
- CGC-11150
- Dextrans
- Fluoresceins
- fluorescein-dextran
- Eflornithine
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Topics |
- Animals
- Apoptosis
- Biogenic Polyamines
(administration & dosage, therapeutic use)
- Bruch Membrane
(surgery)
- Choroidal Neovascularization
(diagnosis, drug therapy, physiopathology)
- Dextrans
- Disease Models, Animal
- Drug Administration Routes
- Eflornithine
(therapeutic use)
- Electroretinography
- Female
- Fluorescein Angiography
- Fluoresceins
- In Situ Nick-End Labeling
- Injections, Intraperitoneal
- Laser Therapy
- Mice
- Mice, Inbred C57BL
- Orbit
- Retina
(physiology)
- Vitreous Body
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