BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice.

Abstract

BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.

• Authors: Britta Hardy, Sara Morgenstern, Annat Raiter, Galina Rodionov, Ludmilla Fadaeev, Yaron Niv
• Journal: Cancer letters (Cancer Lett) Vol. 229 Issue 2 Pg. 217-22 (Nov 18 2005) ISSN: 0304-3835 [Print] Ireland
• PMID: 16122870 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Animals
• Antibodies, Monoclonal (therapeutic use)
• Cell Line, Tumor
• Cell Transplantation
• Colorectal Neoplasms (drug therapy, secondary)
• Humans
• Immunotherapy
• Liver Neoplasms, Experimental (drug therapy, pathology)
• Mice