Abstract | PURPOSE: The aim of our study was to evaluate the prevalence of anticardiolipin and anti-beta2-glikoprotein I (anti-beta2GPI) antibodies in patients with systemic sclerosis (SSc) and to correlate the presence of these antibodies with clinical and serological features of the disease. MATERIAL AND METHODS: 22 patients (21 women and 1 man) fulfilling the ACR classification criteria of SSc were included into the study. In all SSc patients a detailed clinical evaluation including skin and internal organ involvement was performed. Moreover, the measurements of antitopoisomerase I (anti-Scl-70) and anticentromere (ACA) antibodies were done in all patients studied. Anticardiolipin antibodies in IgM and IgG class and anti-beta2GPI antibodies in IgM, IgG and IgA class were evaluated using ELISA kits (Hycor Biomedical and DiaSorin). RESULTS: CONCLUSIONS: The results of our study indicate that the prevalence of anticardiolipin antibodies and anti-beta2GPI antibodies is relatively high in patients with SSc. A more detailed assessment of the relationship between the presence of antiphospholipid antibodies and the clinical and serological features of SSc requires further studies on the larger group of patients and a several years of follow-up.
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Authors | A Sulik, O Kowal-Bielecka, I Domysławska, J Chwiećko, S Sierakowski |
Journal | Roczniki Akademii Medycznej w Bialymstoku (1995)
(Rocz Akad Med Bialymst)
Vol. 50 Suppl 1
Pg. 228-31
( 2005)
Poland |
PMID | 16119673
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Antiphospholipid
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Topics |
- Adult
- Aged
- Antibodies, Antiphospholipid
(blood, immunology)
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Scleroderma, Systemic
(blood, immunology)
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