Abstract | OBJECTIVES: METHODS: All patients received photofrin (PHE) 2 mg/kg intravenously and, 48-60 h later, phototherapy was performed using the Excimer dye laser or a YAG-OPO laser with an irradiation dose of 100 J/cm(2) using 630 nm wavelength. RESULTS: Mild photosensitivity occurred in 48% (50/105) of patients. The complete response (CR) rate was 90% (94/105) at 3 months following treatment. In the remaining 11 patients, 5 patients had CIN1, 2 patients had CIN2, and 4 patients had mild cytologic findings. However, in 9 of these 11 patients, CR was achieved 6 months after PDT. In 69 patients, human papilloma virus (HPV) typing was performed before and after PDT therapy. Pre-treatment, 64 of 69 patients (93%), were HPV-positive including 30 cases of high-risk HPV (43%). Testing performed 3, 6 and 12 months following PDT revealed no HPV- DNA in 75% (52/69), 74% (48/65) and 72% (41/57) of patients. At present, the median follow-up period is 636 days (90-2,232 days). In 3 patients, recurrence requiring surgical treatment was identified at 646, 717 and 895 days after PDT. CONCLUSIONS:
PDT is an effective and minimally invasive treatment for CIN, which also appears to eradicate HPV infection.
|
Authors | Satoshi Yamaguchi, Hiroshi Tsuda, Masayuki Takemori, Shinich Nakata, Sadako Nishimura, Naoki Kawamura, Keisuke Hanioka, Takeshi Inoue, Ryuichiro Nishimura |
Journal | Oncology
(Oncology)
Vol. 69
Issue 2
Pg. 110-6
( 2005)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 16118506
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Dihematoporphyrin Ether
|
Topics |
- Adult
- Antineoplastic Agents
(administration & dosage, adverse effects, therapeutic use)
- Dihematoporphyrin Ether
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
- Papillomavirus Infections
(complications)
- Photochemotherapy
(adverse effects, methods)
- Treatment Outcome
- Uterine Cervical Neoplasms
(drug therapy, pathology, virology)
- Uterine Cervical Dysplasia
(drug therapy, pathology, virology)
|