Abstract | BACKGROUND: OBJECTIVE: The aim of this report was to describe the pharmacodynamic and pharmacokinetic (PK) properties of anidulafungin. METHODS: Data were identified using MEDLINE and National Library of Medicine Gateway searches for English-language literature (key words: anidulafungin, esophageal candidiasis, echinocandin, caspofungin, ravuconazole, voriconazole, posaconazole, micafungin, and fluconazole; years: 1996-2004), and from meeting abstracts of the American Society for Blood and Marrow Transplantation (Arlington Heights, Illinois), European Congress of Clinical Microbiology and Infectious Diseases (Basel, Switzerland), International Conference on Antimicrobial Agents and Chemotherapy (Washington, DC), and Infectious Diseases Society of America (Arlington, Virginia). RESULTS:
Anidulafungin has potent in vitro activity against Aspergillus and Candida spp, including those resistant to either fluconazole or amphotericin B. Results of several clinical trials imply that anidulafungin is effective in treating esophageal candidiasis (EC), candidemia, and invasive candidiasis (IC). In a Phase III, randomized, blinded clinical trial evaluating anidulafungin (50 mg/d) versus fluconazole (100 mg/d) for the treatment of EC, 97.2% and 98.9% of patients who received anidulafungin and fluconazole, respectively, showed evidence of cure or improvement (treatment difference, -1.6%; 95% CI, -4.1 to 0.8). In a Phase II study of candidasis and candidemia, anidulafungin showed success rates of 72%, 85%, and 83% in patients receiving the drug at dosages of 50, 75, or 100 mg/d, respectively. Studies evaluating the concomitant use of anidulafungin and either amphotericin, voriconazole, or cyclosporine did not show clinically significant drug-drug interactions or altered adverse-event (AE) profiles (P < 0.05). A population PK analysis showed no significant effect of age, race, concomitant medications, or renal or hepatic insufficiency on the PK properties of anidulafungin (P < 0.05). CONCLUSIONS:
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Authors | José A Vazquez |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 27
Issue 6
Pg. 657-73
(Jun 2005)
ISSN: 0149-2918 [Print] United States |
PMID | 16117974
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antifungal Agents
- Echinocandins
- Peptides, Cyclic
- Anidulafungin
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Topics |
- Anidulafungin
- Animals
- Antifungal Agents
(pharmacology, therapeutic use)
- Area Under Curve
- Candida
(drug effects)
- Candidiasis
(drug therapy, microbiology)
- Echinocandins
- Humans
- Microbial Sensitivity Tests
- Peptides, Cyclic
(pharmacokinetics, pharmacology, therapeutic use)
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