New substances against human immunodeficiency virus: sulfated 5'-nucleotidase inhibitory polyphenols.

Abstract

Two sulfated polyphenols, NF-86II-S-13.3 and NF-86II-S-6.2, were synthesized from NF-86II without sulfur their inhibitory effect on human immunodeficiency virus (HIV) infection in vitro was examined, using cytopathic effect and an antigen expression assay system in MT-4 cells. NF-86II-S-13.3 (sulfur content, 13.3%) completely inhibited the cytopathic effect of HIV and the HIV-specific antigen expression in MT-4 cells at concentrations of more than 6.3 micrograms/ml. The effect of NF-86II-S-6.2 (sulfur content, 6.2%) was much weaker than that of NF-86IIS-13.3. On the other hand, NF-86II without sulfur did not show any activity at all.

• Authors: T Toukairin, K Uchino, T Mizuno, H Nakashima, N Yamamoto, H Ogawara
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 40 Issue 3 Pg. 802-4 (Mar 1992) ISSN: 0009-2363 [Print] Japan
• PMID: 1611696 (Publication Type: Journal Article)

Chemical References

• Benzenesulfonates
• Biopolymers
• HIV Antigens
• Phenols
• Polymers
• NF 86II
• NF 86II sulfate
• 5'-Nucleotidase

Topics

• 5'-Nucleotidase (antagonists & inhibitors)
• Benzenesulfonates (chemical synthesis, pharmacology)
• Biopolymers
• Cell Division (drug effects)
• Cell Line
• Cytopathogenic Effect, Viral (drug effects)
• HIV (drug effects, physiology)
• HIV Antigens (analysis)
• Humans
• Phenols (chemistry)
• Polymers (chemical synthesis, chemistry, pharmacology)