Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia.

Abstract

Curcumin, a major yellow pigment of turmeric obtained from powdered rhizomes of the plant Curcuma longa Linn., is commonly used as a coloring agent in foods, drugs and cosmetics. Ascorbyl palmitate is a lipid soluble derivative of ascorbic acid. Both curcumin and ascorbyl palmitate have antioxidant activity and are potent inhibitors of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. The effects of dietary curcumin and ascorbyl palmitate on azoxymethanol (AOM)-induced hyperproliferation of colonic epithelial cells and the incidence of focal areas of dysplasia (FADs) were evaluated in female CF-1 mice fed an AIN 76A diet. Subcutaneous injections of AOM (10 mg/kg body wt. once weekly for 6 weeks) caused hyperplasia and the formation of FADs in the colon. Administration of 2% curcumin in the diet inhibited AOM-induced formation of FADs while administration of 2% ascorbyl palmitate in the diet did not demonstrate inhibition. This result suggests that dietary curcumin may inhibit AOM-induced colonic neoplasia in mice.

• Authors: M T Huang, E E Deschner, H L Newmark, Z Y Wang, T A Ferraro, A H Conney
• Journal: Cancer letters (Cancer Lett) Vol. 64 Issue 2 Pg. 117-21 (Jun 15 1992) ISSN: 0304-3835 [Print] Ireland
• PMID: 1611594 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antioxidants
• Methylazoxymethanol Acetate
• Curcumin
• methylazoxymethanol
• Tetradecanoylphorbol Acetate
• Ascorbic Acid
• 6-O-palmitoylascorbic acid

Topics

• Animals
• Antioxidants (pharmacology)
• Ascorbic Acid (administration & dosage, analogs & derivatives, pharmacology)
• Body Weight
• Colon (drug effects, pathology)
• Curcumin (administration & dosage, pharmacology)
• Diet
• Epithelium (drug effects)
• Female
• Methylazoxymethanol Acetate (analogs & derivatives, toxicity)
• Mice
• Tetradecanoylphorbol Acetate (toxicity)