Abstract | BACKGROUND: Dietary antioxidants with yet unproven efficacies in averting prostate cancer (PCa) are widely used in the United States as preventives. Experimental evidence establishing a causal relationship between oxidative and nitrosative stress (OS/NS) and PCa development and showing its modulation by dietary antioxidants would help justify their usage. METHODS: RESULT: We show, for the first time, that oxidative/nitrosative damages of genomic DNA and cellular proteins were discretely localized in premalignant lesions, but not in adjacent morphologically normal epithelia, of TRAMP prostates; these injuries were absent in age-matched nontransgenic littermates. The extent of OS/NS-related injuries correlated well with the tempo of development and prevalence of premalignant lesions in various prostatic lobes and exhibited a clear trend of increase from 12 to 20 weeks of age. Treatment of TRAMP mice with various antioxidants as dietary supplements resulted in differential alleviation of OS/NS-related prostatic injuries. The antioxidant potencies of the dietary supplements did not fully correlate with their documented antiPCa actions, suggest that they may exert additional "nonantioxidant," antitumor effects in this model. CONCLUSIONS:
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Authors | Neville N C Tam, Abraham Nyska, Robert R Maronpot, Grace Kissling, Liat Lomnitski, Andrew Suttie, Shlomo Bakshi, Margalit Bergman, Shlomo Grossman, Shuk-Mei Ho |
Journal | The Prostate
(Prostate)
Vol. 66
Issue 1
Pg. 57-69
(Jan 01 2006)
ISSN: 0270-4137 [Print] United States |
PMID | 16114064
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright (c) 2005 Wiley-Liss, Inc. |
Chemical References |
- Anticarcinogenic Agents
- Antioxidants
- Plant Extracts
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Topics |
- Adenocarcinoma
(pathology, prevention & control)
- Administration, Oral
- Animals
- Anticarcinogenic Agents
(administration & dosage, therapeutic use)
- Antioxidants
(administration & dosage, therapeutic use)
- Diet
- Male
- Mice
- Mice, Transgenic
- Oxygen Consumption
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Prostatic Neoplasms
(pathology, prevention & control)
- Spinacia oleracea
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