The evolving challenge of managing patients with
congestive heart failure is the need to develop new therapeutic strategies. The cellular, molecular, and genetic approaches investigated aim to reinforce the weak, failing heart muscle while restoring its functional potential. This approach is principally cellular
therapy (i.e. cellular
cardiomyoplasty), the preferred therapeutic choice because of its clinical applicability and regenerative capacity. Different stem cells: bone marrow cells, skeletal and smooth muscle cells, vascular endothelial cells, mesothelial cells, adipose tissue stroma cells, dental stem cells, and embryonic and fetal cells, have been proposed for regenerative medicine and biology.
Stem cell mobilization with
G-CSF cytokine was also proposed as a single
therapy for
myocardial infarction. We investigated the association of
cell therapy with electrostimulation (dynamic cellular
cardiomyoplasty), the use of autologous human serum for cell cultures, and a new
catheter for simultaneous
infarct detection and cell delivery. Our team conducted cell-based myogenic and angiogenic clinical trials for chronic
ischemic heart disease. Cellular
cardiomyoplasty constitutes a new approach for myocardial regeneration; the ultimate goal is to avoid the progression of
ventricular remodeling and
heart failure for patients presenting with ischemic and non-ischemic
cardiomyopathies.