[Age-related characteristics of the effects of epithalamin on serotonin metabolism in the pineal gland of rats].

Abstract

The biosynthesis of serotonin into melatonin was decreased in old (18-20-month) in comparison to young (4-5-month) male Wistar rats. 5-day morning injections to young and old rats with polypeptide pineal preparation (epithalamin) in a dose of 2.5 mg/kg of body weight induced the increase in the night peak of serotonin, N-acetylserotonin and melatonin in young and melatonin alone in old rats and did not influence 5-methoxytryptamine, 5-oxy- and 5-methoxyindoleacetic acids level. These data support suggestion of ultrashort loop between pineal peptides and indoles and that epithalamin increases the metabolism of serotonin into melatonin.

• Authors: L A Bondarenko, V N Anisimov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 113 Issue 2 Pg. 194-5 (Feb 1992) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vozrastnye osobennosti vliianiia épitalamina na metabolizm serotonina v shishkovidnoĭ zheleze u krys.
• PMID: 1611074 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Peptides
• Serotonin
• epithalamin
• Melatonin

Topics

• Aging
• Animals
• Male
• Melatonin (biosynthesis)
• Peptides (pharmacology)
• Pineal Gland (drug effects, metabolism)
• Rats
• Rats, Inbred Strains
• Serotonin (metabolism)