Abstract | OBJECTIVE: BACKGROUND: Modulation of the 5-hydroxytryptamine (5-HT) system is used for the neuropharmacology of migraine treatment; however, the involvement of the 5-HT1A system in migraine is not fully understood. METHODS: Seventy-four outpatients aged 20 to 70 years (mean, 46.4; SD, 12.8) were analyzed. All subjects were diagnosed to have migraine according to the International Headache Society criteria and anxiety disorder according to DSM-IV. Subjects were randomly assigned to treatment with either buspirone (10 mg/day) or placebo for 6 weeks. Efficacy variables included changes in headache frequency, headache intensity, Hamilton Anxiety Rating Scale (HAM-A), Headache Self-Efficacy Scale (HMSE), and Headache Disability Inventory (HDI). The correlation between the headache improvement and the anxiolytic effect was analyzed. RESULTS:
Headache frequency showed a 43.3% reduction in the buspirone-treated group, but by only 10.3% in the placebo group. HAM-A and HDI were also significantly more lowered in buspirone-treated patients than in placebo-treated patients. However, headache intensity and HMSE score were unchanged. Correlation analysis of the relation between headache frequency reduction and HAM-A improvement, revealed no significant association. CONCLUSIONS: In this study, buspirone showed a prophylactic effect in migraine with anxiety disorder, which was not secondary to its anxiolytic effect. This suggests that the agonistic action for 5-HT1A can be directly effective in migraine prophylaxis. However, more long-term study is warranted before concluding the efficacy.
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Authors | Soon-Tae Lee, Jong-Ha Park, Manho Kim |
Journal | Headache
(Headache)
Vol. 45
Issue 8
Pg. 1004-11
(Sep 2005)
ISSN: 0017-8748 [Print] United States |
PMID | 16109114
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Anxiety Agents
- Serotonin Receptor Agonists
- Buspirone
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Topics |
- Adult
- Anti-Anxiety Agents
(therapeutic use)
- Anxiety Disorders
(complications, drug therapy)
- Buspirone
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Migraine without Aura
(prevention & control, psychology)
- Multivariate Analysis
- Prospective Studies
- Serotonin Receptor Agonists
(therapeutic use)
- Treatment Outcome
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