Abstract | BACKGROUND: METHODS: To investigate the effect of noscapine on ACEI-induced cough, 611 hypertensive patients who were being treated with ACEI were evaluated for the incidence of persistent dry cough. RESULTS: A cough had developed in 65 (10.6%) patients, two (3.1%) of whom also had severe respiratory distress that required hospitalisation and immediate discontinuation of the ACEI. Forty-two (64.6%) patients had developed a mild cough and 21 (32.3%) patients had developed a moderate to severe cough. The patients with moderate to severe cough received 15 mg of noscapine, orally three times daily, while they continued ACEI. Noscapine effectively resolved the cough in 19 (90%) patients within 4-9 days of starting treatment. CONCLUSION:
Noscapine, possibly by inhibition of bradykinin synthesis, eliminates ACEI-induced cough in the majority of patients and allows them to continue with ACEI therapy.
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Authors | Ahmad Mooraki, Aria Jenabi, Mosadegh Jabbari, Mohammad I Zolfaghari, Sahar Z Javanmardi, Masoud Mahmoudian, Bahar Bastani |
Journal | Nephrology (Carlton, Vic.)
(Nephrology (Carlton))
Vol. 10
Issue 4
Pg. 348-50
(Aug 2005)
ISSN: 1320-5358 [Print] Australia |
PMID | 16109080
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antitussive Agents
- Noscapine
- Bradykinin
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Topics |
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(adverse effects)
- Antitussive Agents
(therapeutic use)
- Bradykinin
(physiology)
- Cough
(etiology, prevention & control)
- Female
- Humans
- Hypertension
(drug therapy)
- Male
- Middle Aged
- Noscapine
(therapeutic use)
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