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Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes.

AbstractAIM: To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of attained weight. RESEARCH DESIGN AND METHODS: Data were obtained from a longitudinal study of two cohorts: one of juvenile-onset obese (n = 248) and one of randomly selected control (n = 320) men, weighed at average ages of 20, 33, 44 and 51 years, respectively. RESULTS: For any given BMI, the risk of IGT was higher the greater the weight gain since age 20 (odds ratio of 1.10 per unit kg/m2 of BMI gain, confidence interval 1.03-1.17, P = 0.004), and weight gain during both the early and later ages contributed to the increased risk. Obese men, maintaining weight since age 20, had lower risk of IGT than non-obese men who became similarly obese by age 51. The risk of Type 2 diabetes increased by weight gain in early adult life, but not by more recent weight gain in the later periods, probably because of the development of Type 2 diabetes leading to weight loss. CONCLUSIONS: Independent of attained level of body weight in middle-aged men, weight gain is associated with increased risk of IGT, and is greater in those not overweight in childhood.
AuthorsE Black, C Holst, A Astrup, S Toubro, S Echwald, O Pedersen, T I A Sørensen (Affiliation: Department of Human Nutrition, Centre of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark.)
JournalDiabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 22 Issue 9 Pg. 1199-205 (Sep 2005) ISSN: 0742-3071 England
PMID16108849 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
Topics
  • Adult
  • Aging (physiology)
  • Blood Glucose (analysis)
  • Body Mass Index
  • Diabetes Mellitus, Type 2 (epidemiology, etiology, physiopathology)
  • Glucose Intolerance (epidemiology, etiology, physiopathology)
  • Glucose Tolerance Test (methods)
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Obesity (physiopathology)
  • Prevalence
  • Risk Factors
  • Weight Gain (physiology)