Abstract | UNLABELLED: The purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer. METHODS: The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10. RESULTS: The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups. CONCLUSION: Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients.
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Authors | V Dousias, T Stefos, I Navrozoglou, I Staikos, A Ditto, E Paraskevaidis |
Journal | Clinical and experimental obstetrics & gynecology
(Clin Exp Obstet Gynecol)
Vol. 32
Issue 2
Pg. 129-31
( 2005)
ISSN: 0390-6663 [Print] Singapore |
PMID | 16108399
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Iron Compounds
- Recombinant Proteins
- Erythropoietin
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Topics |
- Adult
- Aged
- Confidence Intervals
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Erythropoietin
(administration & dosage)
- Female
- Follow-Up Studies
- Genital Neoplasms, Female
(drug therapy, mortality, pathology, surgery)
- Gynecologic Surgical Procedures
(methods, mortality)
- Humans
- Iron Compounds
(administration & dosage)
- Middle Aged
- Neoplasm Staging
- Preoperative Care
- Probability
- Prospective Studies
- Recombinant Proteins
- Reference Values
- Risk Assessment
- Survival Analysis
- Treatment Outcome
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