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Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery.

AbstractUNLABELLED:
The purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer.
METHODS:
The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10.
RESULTS:
The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups.
CONCLUSION:
Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients.
AuthorsV Dousias, T Stefos, I Navrozoglou, I Staikos, A Ditto, E Paraskevaidis
JournalClinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 32 Issue 2 Pg. 129-31 ( 2005) ISSN: 0390-6663 [Print] Italy
PMID16108399 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Iron Compounds
  • Recombinant Proteins
  • Erythropoietin
Topics
  • Adult
  • Aged
  • Confidence Intervals
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Erythropoietin (administration & dosage)
  • Female
  • Follow-Up Studies
  • Genital Neoplasms, Female (drug therapy, mortality, pathology, surgery)
  • Gynecologic Surgical Procedures (methods, mortality)
  • Humans
  • Iron Compounds (administration & dosage)
  • Middle Aged
  • Neoplasm Staging
  • Preoperative Care
  • Probability
  • Prospective Studies
  • Recombinant Proteins
  • Reference Values
  • Risk Assessment
  • Survival Analysis
  • Treatment Outcome

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