Taurine was discovered more than two hundred years ago from animal sources. It is distributed in both mammals and non-mammals and its content is high in several tissues. For more than a century-and-a-half,
taurine was regarded just as an end product of
sulfur metabolism. Recently,
taurine has been rediscovered and its beneficial effects in processes like
epilepsy,
hypertension,
congestive heart failure and diabetes have been well-documented. It was patented and found some clinical utility, but being an
amino acid,
therapeutic use confronts limitations like restricted permeability and more. This necessitates the development of
pro-drugs (analogues) mainly derivatives of
taurine. A large number of
taurine derivatives have been reported in the literature with partial to marked activity.
Taurine derivatives like
taltrimide,
acamprosate and
tauromustine, are already in the market as anti-
convulsant, anti-alcoholic and anti-
cancer agents. Many other analogues are effective in experimental models. The in depth analysis of these analogues and their
biological actions can provide certain clues for further consideration. In the present review, attempts have been made to provide synopsis, synthesis and symbiosis of chemical and
biological actions, which may provide future guidance and facilitate further research in this area. The successful journey of these analogues to clinical utility is a healthy and happy sign and an index of bright future, and we hope that this review will provide enough input to ignite the minds.