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[Cytochrome P4502E1. Polymorphism, physiological function, regulation, and role in pathology].

Abstract
The role of cytochrome P4502E1 in metabolism of substances, polymorphism, ways of the expression regulation, change of activity in pathological condition is considered in the review. Cytochrome P4502E1 catalyzed first two reactions of acetone transformation in the lactic acid, ethanol oxidation, metabolism of fatty acids and their hydroperoxides. Cytochrome P4502E1 dependent metabolism of xenobiotics in many cases results in formation of toxic intermediates and radicals of oxygen. Regulation of cytochrome P4502E1 expression includes transcriptional mechanisms and substrate stabilization of its molecule. The enzyme activity grows in alcoholism, diabetes mellitus, obesity, steatohepatitis, administration of acetone, alcohols and is connected with intensification of toxicity of paracetamol, halothane, benzene, tetrachlororomethane and others xenobiotics. Such inhibitors of cytochrome P4502E1 as dialyl sulphide, disulfiram have hepatoprotective action.
AuthorsO O Pentiuk, S O Kachula, O Kh Herych
JournalUkrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2004 Sep-Oct Vol. 76 Issue 5 Pg. 16-28 Ukraine
Vernacular TitleTsytokhrom P-4502E1. Polimorfizm, fiziolohichni funktsiï, rehuliatsiia, rol' u patolohiï.
PMID16100894 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Xenobiotics
  • Cytochrome P-450 CYP2E1
Topics
  • Animals
  • Cytochrome P-450 CYP2E1 (genetics, metabolism, physiology)
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Polymorphism, Genetic
  • Substrate Specificity
  • Xenobiotics (metabolism)

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