Rifampicin+ceftriaxone versus vancomycin+ceftriaxone in the treatment of penicillin- and cephalosporin-resistant pneumococcal meningitis in an experimental rabbit model.

Abstract	This study was planned to compare the efficacy of ceftriaxone+vancomycin with ceftriaxone+rifampicin in a rabbit model of penicillin and cephalosporin-resistant Streptococcus pneumoniae meningitis. Meningitis was induced by intracisternal inoculation of S. pneumoniae. After 18 h of incubation, Group 1 was given saline solution (control group), whilst Groups 2 and 3 were given ceftriaxone+vancomycin and ceftriaxone+rifampicin, respectively. Cerebrospinal fluid bacterial concentrations were measured at 0, 2, 12, 14 and 24 h after therapy was initiated. In the control group, bacterial growth was present at all time points, whereas no growth was observed in either the ceftriaxone+vancomycin group or the ceftriaxone+rifampicin group after 2 h of therapy. Ceftriaxone+rifampicin was found to be as effective as ceftriaxone+vancomycin in the treatment of penicillin-resistant S. pneumoniae meningitis in experimental rabbit model.
Authors	Bedia Mutay Suntur, Taskin Yurtseven, Oguz Resat Sipahi, Cagri Buke, Munir Buke
Journal	International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 26 Issue 3 Pg. 258-60 (Sep 2005) ISSN: 0924-8579 [Print] Netherlands
PMID	16099624 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Bacterial Agents Vancomycin Ceftriaxone Rifampin
Topics	Animals Anti-Bacterial Agents (administration & dosage, pharmacology, therapeutic use) Ceftriaxone (administration & dosage, pharmacology, therapeutic use) Cephalosporin Resistance Cerebrospinal Fluid (microbiology) Disease Models, Animal Drug Resistance, Bacterial Drug Therapy, Combination Meningitis, Meningococcal (drug therapy, microbiology) Penicillin Resistance Rabbits Rifampin (administration & dosage, pharmacology, therapeutic use) Streptococcus pneumoniae (drug effects) Vancomycin (administration & dosage, pharmacology, therapeutic use)

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