Abstract |
Radiation sickness is frequently observed in total body irradiation (TBI). We have reported that the kaolin ingestion behavior " pica" may be analogous to nausea and vomiting in mice. We evaluated the effects of anti-emetics on the prevention of radiation-induced pica in mice. After the intraperitoneal injection of ondansetron (OND: 2 mg/kg), dexamethasone (DEX: 2 mg/kg) or CP-99,994 (CP: 15 mg/kg), mice received 9 Gy of TBI, and then kaolin consumption was measured after 24 h. Radiation-induced pica was slightly inhibited by pretreatment with a single administration of OND or DEX, but not by CP (control: 0.69+/-0.19 g, OND: 0.33+/-0.06 g, DEX: 0.39+/-0.07 g, CP: 0.66+/-0.09 g); it was significantly inhibited by the combination treatment of OND and DEX (control: 0.55+/-0.09 g, OND+DEX: 0.30+/-0.06 g, OND+CP: 0.70+/-0.04 g, DEX+CP: 0.58+/-0.02 g). The combination of the three drugs completely abolished the behavior (control: 0.67+/-0.08 g, OND+DEX+CP: 0.10+/-0.05 g). These results suggest that radiation-induced pica in mice may be useful to evaluate drugs for treatment of radiation sickness and that the combination therapy of a serotonin 5-HT3 receptor antagonist and a glucocorticosteroid with a neurokinin NK1 receptor antagonist is effective in reducing the symptom.
|
Authors | Kouichi Yamamoto, Kyoko Nohara, Tomohisa Furuya, Atsushi Yamatodani |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 82
Issue 1
Pg. 24-9
(Sep 2005)
ISSN: 0091-3057 [Print] United States |
PMID | 16098569
(Publication Type: Journal Article)
|
Chemical References |
- Antiemetics
- Neurokinin-1 Receptor Antagonists
- Piperidines
- Serotonin Antagonists
- 3-(2-methoxybenzylamino)-2-phenylpiperidine
- Ondansetron
- Dexamethasone
|
Topics |
- Animals
- Antiemetics
(administration & dosage, pharmacology)
- Dexamethasone
(administration & dosage, pharmacology)
- Drug Therapy, Combination
- Male
- Mice
- Mice, Inbred ICR
- Neurokinin-1 Receptor Antagonists
- Ondansetron
(administration & dosage, pharmacology)
- Pica
(chemically induced, prevention & control)
- Piperidines
(administration & dosage, pharmacology)
- Radiation Injuries
(prevention & control)
- Serotonin Antagonists
(administration & dosage, pharmacology)
|