Abstract |
We performed basic and clinical studies on the effects of a new oral quinolone derivative, levofloxacin (LVFX, Code No. DR 3355) which is an optical l-isomer of ofloxacin, in acute epididymitis. LVFX was administered in a dose of 200 mg to prostatic cancer patients 2 hours before operation. The mean concentration of LVFX in the tissues of testis and epididymis were 4.73 micrograms/g and 313-3.6 micrograms/g, respectively. Tissue/Serum ratios were 1.63 and 1.16-1.32, respectively. LVFX was administered in a dose of 100 mg three times daily for 13 days to healthy male volunteers. Semen and blood samples were taken 2 hrs after 7th and last day of administration. The concentration of LVFX in semen were 1.19 micrograms/ml (7th day) and 1.32 micrograms/ml (13th day). Semen/serum ratios were 1.12 and 1.26, respectively. No affection of LVFX on the sperm was observed. Antimicrobial activity of LVFX to C. trachomatis showed good MICs of 0.25-1.0 micrograms/ml. LVFX was administered in a dose of 100 mg two or three times daily for 14 days to 23 patients with acute epididymitis. The overall efficacy rate based on a criteria for acute epididymitis showed 100% (excellent: 16, good: 4, 20/20). A better efficacy rate was obtained on the 14th day than 7th day. No subjective or objective adverse reactions were observed.
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Authors | I Saito, A Suzuki, Y Saiko, M Yokozawa, K Ono, K Miyata, R Miyamura, O Hamaya, K Kaneko, T Yamamoto |
Journal | Hinyokika kiyo. Acta urologica Japonica
(Hinyokika Kiyo)
Vol. 38
Issue 5
Pg. 623-8
(May 1992)
ISSN: 0018-1994 [Print] Japan |
PMID | 1609677
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Acute Disease
- Administration, Oral
- Adult
- Chlamydia trachomatis
(drug effects)
- Epididymis
(metabolism)
- Epididymitis
(drug therapy, microbiology, physiopathology)
- Humans
- Levofloxacin
- Male
- Middle Aged
- Ofloxacin
(pharmacokinetics, pharmacology, therapeutic use)
- Sperm Count
(drug effects)
- Sperm Motility
(drug effects)
- Spermatozoa
(drug effects)
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