Abstract |
A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine ( PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP- PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.
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Authors | D Scheifele, G Bjornson, L Barreto, W Meekison, R Guasparini |
Journal | Vaccine
(Vaccine)
Vol. 10
Issue 7
Pg. 455-60
( 1992)
ISSN: 0264-410X [Print] Netherlands |
PMID | 1609548
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Bacterial Vaccines
- Diphtheria Toxoid
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate
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Topics |
- Arm
- Bacterial Vaccines
(administration & dosage)
- Diphtheria Toxoid
(administration & dosage)
- Diphtheria-Tetanus-Pertussis Vaccine
(administration & dosage)
- Haemophilus Vaccines
- Humans
- Infant
- Injections, Intramuscular
- Leg
- Vaccination
(methods)
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