HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection.

Abstract
A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.
AuthorsD Scheifele, G Bjornson, L Barreto, W Meekison, R Guasparini
JournalVaccine (Vaccine) Vol. 10 Issue 7 Pg. 455-60 ( 1992) ISSN: 0264-410X [Print] Netherlands
PMID1609548 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Bacterial Vaccines
  • Diphtheria Toxoid
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate
Topics
  • Arm
  • Bacterial Vaccines (administration & dosage)
  • Diphtheria Toxoid (administration & dosage)
  • Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage)
  • Haemophilus Vaccines
  • Humans
  • Infant
  • Injections, Intramuscular
  • Leg
  • Vaccination (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: