Abstract | PURPOSE OF REVIEW: The purpose of this article is to review the foundational work and current developments on a group of rheumatic disorders associated with mutations in the caspase recruitment domain 15/ nucleotide oligomerization domain 2 gene. RECENT FINDINGS: SUMMARY: Although histologically, Crohn's disease and familial and sporadic sarcoid granulomatous arthritis are distinct from rheumatoid arthritis because of the defining presence (albeit in not all cases) of non-caseating granulomata in the synovial and intestinal tissues, respectively, they still represent a promising model of both chronic synovitis and uveitis. In addition, once the actual mechanism is discovered by which defects of the caspase recruitment domain 15 gene product lead to chronic arthritis, it may uncover unsuspected biologic targets for therapeutics.
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Authors | Carlos D Rose, Tammy M Martin |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 17
Issue 5
Pg. 579-85
(Sep 2005)
ISSN: 1040-8711 [Print] United States |
PMID | 16093837
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Caspases
(chemistry, genetics)
- Humans
- Mutation
- Protein Structure, Tertiary
- Rheumatic Diseases
(genetics)
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