Cost savings from intravenous immunoglobulin manufactured from chromotography/caprylate (IGIV-C) in persons with primary humoral immunodeficiency disorder.

Abstract

OBJECTIVE:

Human intravenous immunoglobulin manufactured with chromatography and caprylate methods (IGIV-C, 10%) was associated with a reduction in validated infections (pneumonia and sinusitis) compared with treatment with a licensed immunoglobulin product manufactured using standard solvent-detergent methods (IGIV-SD, 10%) in participants with primary humoral immunodeficiency disorder (PIDD). Our objective was to determine the cost-consequences of using IGIV-C instead of IGIV-SD.

METHODS:

Economic analysis of a double-blind, randomized, clinical trial was used. Participants were randomly assigned to IGIV-C (N = 87) or IGIV-SD (N = 85) and monitored for the development of validated infections over the course of 9 months. Consumed resources were enumerated including cost of physician and emergency room visits, medications (prescription and over-the-counter), work productivity losses, and hospitalizations. Resource data was obtained from case report forms, patient diaries and the trial medication database. Because the amount of IGIV-SD used exceeded that of IGIV-C (nonstatistically significant difference) and the products are equivalently priced, we conservatively excluded investigational product acquisition cost to avoid artificially biasing incremental cost differences. We used a societal perspective with indirect costs, measured in 2003 US dollars. Pricing of both IGIV products is anticipated to be equivalent.

RESULTS:

In a multivariate analysis, annual mean per participant costs were significantly lower between those receiving IGIV-C compared with IGIV-SD for prescription medications [-US 302 dollars, 95% confidence interval (CI) -US 598 dollars to -US 6 dollars], hospitalization (-US 1454 dollars, 95% CI -US 1828 dollars to -US 1080 dollars) and total costs (-US 1304 dollars, 95% CI -US 1867 dollars to -US 742 dollars). Costs associated with lost work productivity and physician visits were similar in both groups (P > 0.10). In sensitivity analyses, varying costs of concomitant medications, hospitalization and outpatient care, did not significantly change our results.

CONCLUSION:

IGIV-C is cost-saving compared with IGIV-SD among persons with PIDD.

• Authors: Parthiv J Mahadevia, John Strell, Dan Kunaprayoon, Erwin Gelfand
• Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research (Value Health) 2005 Jul-Aug Vol. 8 Issue 4 Pg. 488-94 ISSN: 1098-3015 [Print] United States
• PMID: 16091026 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Caprylates
• Immunoglobulins, Intravenous

Topics

• Adult
• Canada
• Caprylates
• Chromatography
• Cost Savings
• Cost of Illness
• Drug Contamination (economics, prevention & control)
• Female
• Humans
• Immunoglobulins, Intravenous (adverse effects, economics)
• Immunologic Deficiency Syndromes (drug therapy, economics)
• Likelihood Functions
• Male
• Models, Econometric
• Multivariate Analysis
• Randomized Controlled Trials as Topic
• Respiratory Tract Infections (economics, prevention & control)
• Retrospective Studies
• Technology, Pharmaceutical (economics)
• United States