Paradoxical intracranial tuberculoma requiring surgical treatment.

Paradoxical enlargement of intracranial tuberculomas or development of new ones during adequate antituberculous chemotherapy is an uncommon event. Treatment of such cases is controversial. Steroid therapy is usually advocated without change in the antituberculous drug program. However, in some patients whose lesions fail medical treatment, or who have superficially located large lesions, surgical therapy may be required. A 15-year-old girl with pulmonary miliary tuberculosis, tuberculous meningitis and multiple intracranial tuberculomas is presented. While her pulmonary lesions and intracranial tuberculomas except one were healed with chemotherapy, one tuberculoma increased in size 1 month after starting chemotherapy. She was followed with dexamethasone treatment in addition to antituberculous therapy for 2 months. Then, the lesion was removed because it had increased in size in spite of appropriate chemotherapy.
AuthorsN Serdar Bas, Feyza Karagöz Güzey, Erhan Emel, Ibrahim Alatas, Baris Sel
JournalPediatric neurosurgery (Pediatr Neurosurg) 2005 Jul-Aug Vol. 41 Issue 4 Pg. 201-5 ISSN: 1016-2291 [Print] Switzerland
PMID16088256 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antitubercular Agents
  • Glucocorticoids
  • Dexamethasone
  • Adolescent
  • Antitubercular Agents (therapeutic use)
  • Dexamethasone (therapeutic use)
  • Female
  • Frontal Lobe (pathology, surgery)
  • Glucocorticoids (therapeutic use)
  • Humans
  • Treatment Failure
  • Tuberculoma, Intracranial (drug therapy, pathology, surgery)

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