Abstract | OBJECTIVE: To compare the anatomical and visual outcomes of primary idiopathic macular hole surgery using indocyanine green-assisted internal limiting membrane peeling versus no internal limiting membrane peeling. DESIGN: Prospective randomised controlled clinical trial. SETTING: University teaching hospital, Hong Kong. PATIENTS: Fifty-one eyes of 49 Chinese patients with primary idiopathic macular hole were studied. INTERVENTIONS: Patients were randomised to undergo pars plana vitrectomy with indocyanine green-assisted internal limiting membrane peeling (26 eyes) or surgery without internal limiting membrane peeling (25 eyes). Perfluorocarbon gas was used in all cases as internal tamponade. MAIN OUTCOME MEASURES: Primary macular hole closure rate and best-corrected visual acuity. RESULTS: The mean follow-up duration was 12 months (range, 6-23 months). Respectively to the indocyanine green-assisted internal limiting membrane peeling group and non-internal limiting membrane peeling group, the primary anatomical closure rate was 92.3% and 32.0% (P<0.001), whereas improvement in best-corrected visual acuity was 3.7 and 1.5 lines (P=0.002). More eyes in the first group (84.6%) had improvement of 2 or more lines of best-corrected visual acuity after surgery than in the second group (32.0%) [P<0.001]. Multivariate logistic regression showed indocyanine green-assisted internal limiting membrane peeling was the only significant predictor for primary closure of the macular hole (adjusted odds ratio=30.8). CONCLUSION:
Indocyanine green-assisted internal limiting membrane peeling in idiopathic macular hole surgery results in significantly better anatomical and visual outcomes compared with non-internal limiting membrane peeling in Chinese patients.
|
Authors | A K H Kwok, T Y Y Lai, V W Y Wong |
Journal | Hong Kong medical journal = Xianggang yi xue za zhi
(Hong Kong Med J)
Vol. 11
Issue 4
Pg. 259-66
(Aug 2005)
ISSN: 1024-2708 [Print] China |
PMID | 16085942
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Coloring Agents
- Indocyanine Green
|
Topics |
- Adolescent
- Coloring Agents
(administration & dosage)
- Epiretinal Membrane
(surgery)
- Hong Kong
- Humans
- Indocyanine Green
(administration & dosage)
- Logistic Models
- Multivariate Analysis
- Postoperative Complications
- Prospective Studies
- Retina
(pathology, surgery)
- Retinal Detachment
(etiology)
- Retinal Perforations
(surgery)
- Treatment Outcome
- Vision, Ocular
- Vitrectomy
(methods)
|