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Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia.

Abstract
Here, we report the diversity of amantadine-resistant mutants among avian influenza A viruses with pandemic potential (H5, H6, H7, and H9 hemagglutinin subtypes). Drug-resistant variants were not detected among 1979--83 isolates, whereas 31.1% of H5 and 10.6% of H9 strains from Southeast Asia isolated in 2000-04 carried mutations in M2 protein. In North America, resistant variants occurred among H7 viruses only (16.4% of those tested). H6 viruses were amantadine-sensitive. These findings prompt concern regarding the control of pandemic influenza, the possibility that the next pandemic virus will be amantadine-resistant and the need to monitor the use of the drug in poultry.
AuthorsNatalia A Ilyushina, Elena A Govorkova, Robert G Webster
JournalVirology (Virology) Vol. 341 Issue 1 Pg. 102-6 (Oct 10 2005) ISSN: 0042-6822 [Print] United States
PMID16081121 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antiviral Agents
  • Amantadine
Topics
  • Amantadine (pharmacology)
  • Animals
  • Antiviral Agents (pharmacology)
  • Asia, Southeastern
  • Cell Line
  • Dogs
  • Drug Resistance, Viral
  • Humans
  • Influenza A virus (classification, drug effects, isolation & purification)
  • Influenza in Birds (drug therapy, virology)
  • North America
  • Poultry

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