Abstract |
Here, we report the diversity of amantadine-resistant mutants among avian influenza A viruses with pandemic potential (H5, H6, H7, and H9 hemagglutinin subtypes). Drug-resistant variants were not detected among 1979--83 isolates, whereas 31.1% of H5 and 10.6% of H9 strains from Southeast Asia isolated in 2000-04 carried mutations in M2 protein. In North America, resistant variants occurred among H7 viruses only (16.4% of those tested). H6 viruses were amantadine-sensitive. These findings prompt concern regarding the control of pandemic influenza, the possibility that the next pandemic virus will be amantadine-resistant and the need to monitor the use of the drug in poultry.
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Authors | Natalia A Ilyushina, Elena A Govorkova, Robert G Webster |
Journal | Virology
(Virology)
Vol. 341
Issue 1
Pg. 102-6
(Oct 10 2005)
ISSN: 0042-6822 [Print] United States |
PMID | 16081121
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antiviral Agents
- Amantadine
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Topics |
- Amantadine
(pharmacology)
- Animals
- Antiviral Agents
(pharmacology)
- Asia, Southeastern
- Cell Line
- Dogs
- Drug Resistance, Viral
- Humans
- Influenza A virus
(classification, drug effects, isolation & purification)
- Influenza in Birds
(drug therapy, virology)
- North America
- Poultry
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