Abstract | BACKGROUND: A highly specific antibody against recombinant human dihydropyrimidine dehydrogenase (DPD) has been developed to immunohistochemically assess DPD expression in tumors. A new oral DPD inhibitory fluoropyrimidine (DIF), S-1, is reportedly effective against gastric scirrhous carcinoma. PATIENTS AND METHODS: In this study, the relationship between immunoreactivity to DPD in biopsy specimens and the effects of chemotherapy were investigated in 61 patients treated with first-line fluoropyrimidine-based chemotherapy (S-1:DIF, 5-FU:non-DIF) for gastric scirrhous carcinoma. RESULTS: The response rate was significantly higher in patients with DPD-positive tumors than in those with DPD-negative tumors in the S-1 group (45.5%, 10.0%: p < 0.05), as compared to the 5-FU group (0%, 5.6%: p = 0.398). According to the median survival time, there was no significant difference between patients with DPD-positive tumors (364 days) and those with DPD-negative tumors (406 days; p = 0.626) in either the S-1 group or the 5-FU group (181 days and 256 days, respectively; p = 0.543). CONCLUSION: This study indicates that S-1 may be effective even in gastric scirrhous carcinoma with a high level of DPD activity.
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Authors | Toshio Shimizu, Yasuhide Yamada, Hisateru Yasui, Kuniaki Shirao, Masahiro Fukuoka |
Journal | Anticancer research
(Anticancer Res)
2005 Jul-Aug
Vol. 25
Issue 4
Pg. 2997-3001
ISSN: 0250-7005 [Print] Greece |
PMID | 16080558
(Publication Type: Journal Article)
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Chemical References |
- Antibodies
- Drug Combinations
- Pyridines
- Recombinant Proteins
- S 1 (combination)
- Tegafur
- Oxonic Acid
- Dihydrouracil Dehydrogenase (NADP)
- Fluorouracil
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Topics |
- Adenocarcinoma, Scirrhous
(drug therapy, enzymology)
- Adult
- Aged
- Antibodies
(chemistry, immunology)
- Antibody Specificity
- Dihydrouracil Dehydrogenase (NADP)
(antagonists & inhibitors, immunology, metabolism)
- Drug Combinations
- Female
- Fluorouracil
(therapeutic use)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Oxonic Acid
(therapeutic use)
- Pyridines
(therapeutic use)
- Recombinant Proteins
(chemistry, immunology)
- Retrospective Studies
- Stomach Neoplasms
(drug therapy, enzymology)
- Tegafur
(therapeutic use)
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