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Clinical application of immunoreactivity of dihydropyrimidine dehydrogenase (DPD) in gastric scirrhous carcinoma treated with S-1, a new DPD inhibitory fluoropyrimidine.

AbstractBACKGROUND:
A highly specific antibody against recombinant human dihydropyrimidine dehydrogenase (DPD) has been developed to immunohistochemically assess DPD expression in tumors. A new oral DPD inhibitory fluoropyrimidine (DIF), S-1, is reportedly effective against gastric scirrhous carcinoma.
PATIENTS AND METHODS:
In this study, the relationship between immunoreactivity to DPD in biopsy specimens and the effects of chemotherapy were investigated in 61 patients treated with first-line fluoropyrimidine-based chemotherapy (S-1:DIF, 5-FU:non-DIF) for gastric scirrhous carcinoma.
RESULTS:
The response rate was significantly higher in patients with DPD-positive tumors than in those with DPD-negative tumors in the S-1 group (45.5%, 10.0%: p < 0.05), as compared to the 5-FU group (0%, 5.6%: p = 0.398). According to the median survival time, there was no significant difference between patients with DPD-positive tumors (364 days) and those with DPD-negative tumors (406 days; p = 0.626) in either the S-1 group or the 5-FU group (181 days and 256 days, respectively; p = 0.543).
CONCLUSION:
This study indicates that S-1 may be effective even in gastric scirrhous carcinoma with a high level of DPD activity.
AuthorsToshio Shimizu, Yasuhide Yamada, Hisateru Yasui, Kuniaki Shirao, Masahiro Fukuoka
JournalAnticancer research (Anticancer Res) 2005 Jul-Aug Vol. 25 Issue 4 Pg. 2997-3001 ISSN: 0250-7005 [Print] Greece
PMID16080558 (Publication Type: Journal Article)
Chemical References
  • Antibodies
  • Drug Combinations
  • Pyridines
  • Recombinant Proteins
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
  • Dihydrouracil Dehydrogenase (NADP)
  • Fluorouracil
Topics
  • Adenocarcinoma, Scirrhous (drug therapy, enzymology)
  • Adult
  • Aged
  • Antibodies (chemistry, immunology)
  • Antibody Specificity
  • Dihydrouracil Dehydrogenase (NADP) (antagonists & inhibitors, immunology, metabolism)
  • Drug Combinations
  • Female
  • Fluorouracil (therapeutic use)
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Oxonic Acid (therapeutic use)
  • Pyridines (therapeutic use)
  • Recombinant Proteins (chemistry, immunology)
  • Retrospective Studies
  • Stomach Neoplasms (drug therapy, enzymology)
  • Tegafur (therapeutic use)

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