Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee.

Abstract

We describe a 21-year-old man with a large osteochondral defect of the knee after septic arthritis, successfully treated by transplant of mesenchymal stem cells (MSC) from bone marrow and a new type of interconnected porous hydroxyapatite ceramic (IP-CHA). We confirmed successful cartilage-like tissue regeneration by a second arthroscopy. Biopsy of the repaired tissue revealed cartilage-like regeneration and bone formation. We were able to regenerate new bone and cartilage-like tissue in a one-stage operation, without sacrificing autologous bone or other tissue. This cultured MSC and IP-CHA hybrid material transplant represents a novel treatment for a severe osteochondral defect after septic arthritis.

• Authors: Nobuo Adachi, Mitsuo Ochi, Masataka Deie, Yohei Ito
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 32 Issue 8 Pg. 1615-8 (Aug 2005) ISSN: 0315-162X [Print] Canada
• PMID: 16078345 (Publication Type: Case Reports, Journal Article)

Chemical References

• Durapatite

Topics

• Adult
• Arthritis, Infectious (pathology, therapy)
• Biopsy
• Cartilage (physiology)
• Ceramics (therapeutic use)
• Combined Modality Therapy
• Durapatite (therapeutic use)
• Humans
• Male
• Mesoderm (cytology)
• Osteoarthritis, Knee (pathology, therapy)
• Regeneration
• Severity of Illness Index
• Stem Cell Transplantation