Abstract |
Pyoderma gangrenosum is an intractable skin disorder characterized by the development of erythematous pustules or nodules that rapidly progress to destructive, necrotizing, non-infective ulcers. We assessed the efficacy of granulocyte and monocyte adsorption apheresis (GCAP) therapy in two new patients, a 67-year-old man with ulcerations on his lower leg, and a 44-year-old man with turgid erythematous lesions with burrowing abscesses and sinus formation on his hip, groin, and thighs. Both patients received 10 GCAP treatments at 5-day intervals. Their skin lesions responded well. The 9 cmx6 cm ulcer on the lower right leg of the 67-year-old patient was completely covered by regenerated skin at the completion of therapy. The turgid skin lesions containing pustules and ulcers of the other patient showed amelioration and a marked decrease in the volume of exudate. Our results suggest that GCAP is a useful treatment modality for pyoderma gangrenosum.
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Authors | Takuro Kanekura, Koichi Kawahara, Ikuro Maruyama, Tamotsu Kanzaki |
Journal | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
(Ther Apher Dial)
Vol. 9
Issue 4
Pg. 292-6
(Aug 2005)
ISSN: 1744-9979 [Print] Australia |
PMID | 16076369
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adsorption
- Adult
- Aged
- Blood Component Removal
(methods)
- Buttocks
- Granulocytes
- Humans
- Leg Ulcer
(therapy)
- Male
- Monocytes
- Pyoderma Gangrenosum
(therapy)
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